EPIFIL: the development of an age-structured model for describing the transmission dynamics and control of lymphatic filariasis.
Identifieur interne : 00A261 ( Main/Exploration ); précédent : 00A260; suivant : 00A262EPIFIL: the development of an age-structured model for describing the transmission dynamics and control of lymphatic filariasis.
Auteurs : R. A. Norman ; M. S. Chan ; A. Srividya ; S. P. Pani ; K. D. Ramaiah ; P. Vanamail ; E. Michael ; P. K. Das ; D. A. BundySource :
- Epidemiology and Infection [ 0950-2688 ] ; 2000.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Culex, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (transmission), Humains, Lutte contre les insectes, Modèles théoriques, Mâle, Nourrisson, Nouveau-né, Sujet âgé, Vecteurs insectes.
- MESH :
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Filaricides, Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Culex, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Femelle, Humains, Lutte contre les insectes, Modèles théoriques, Mâle, Nourrisson, Nouveau-né, Sujet âgé, Vecteurs insectes.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Animals, Child, Child, Preschool, Culex, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (transmission), Female, Filaricides (therapeutic use), Humans, Infant, Infant, Newborn, Insect Control, Insect Vectors, Male, Middle Aged, Models, Theoretical.
- MESH :
- chemical , therapeutic use : Filaricides.
- drug therapy : Elephantiasis, Filarial.
- transmission : Elephantiasis, Filarial.
- Adolescent, Adult, Age Factors, Aged, Animals, Child, Child, Preschool, Culex, Female, Humans, Infant, Infant, Newborn, Insect Control, Insect Vectors, Male, Middle Aged, Models, Theoretical.
Abstract
Mathematical models of transmission dynamics of infectious diseases provide a useful tool for investigating the impact of community based control measures. Previously, we used a dynamic (constant force-of-infection) model for lymphatic filariasis to describe observed patterns of infection and disease in endemic communities. In this paper, we expand the model to examine the effects of control options against filariasis by incorporating the impact of age structure of the human community and by addressing explicitly the dynamics of parasite transmission from and to the vector population. This model is tested using data for Wuchereria bancrofti transmitted by Culex quinquefasciatus in Pondicherry, South India. The results show that chemotherapy has a larger short-term impact than vector control but that the effects of vector control can last beyond the treatment period. In addition we compare rates of recrudescence for drugs with different macrofilaricidal effects.
Url:
PubMed: 10982078
PubMed Central: 2810940
Affiliations:
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Le document en format XML
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